Lung Cancer: Lung Cancer I |

A Case Report of Kaposi Hemangioendothelioma and Literature Analysis FREE TO VIEW

Chen Juan
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The First Affiliated Hospital of Guangzhou Medical, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A297. doi:10.1016/j.chest.2016.02.310
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To eplore the clinical characteristics, diagnosis and treatments of kaposi hemangioendothelioma.

METHODS: Through the Chinese biomedical literature CD database (CBM - Disk), we searched and hunted literature reports about KHE from January 2000 to April 2015, except the cumulative reported cases. Combing with 1 patients admitted in Guangzhou institute of respiratory diseases and the first affiliated hospital of Guangzhou medical university, we retrospectively analyzed the clinical data of KHE in our country.

RESULTS: Among 34 cases of KHE, 17 cases are male, 17 cases are female and the median age is 15.5 months (aged 20 days to 54 years). The cases of which KHE occours are 8 trunks, 6 bones, 6 skins of limbs, 5 head-and-necks, 3 after- peritoneals, 2 mediastinums, 1 spleens, 2 skins of limbs and bone, 1 multifocal lesions. The main clinical manifestations are neoplasms (19 cases), other clinical features include pains (9 cases), erythemas (3 cases) etc. 30case refer to platelet-counts, among which 17 reduced and 13 normal. The pathology of the tumor are composed of spindle cells mainly and present as nodular, and typical pathology change-- glomerular structure occoured in 19 cases. The results of immunohistochemistry is CD34-positives 29 cases, CD31-positives 24cases, Vimentin-positives 14 cases. The results about treaments are 14 operations, 6 chemotherapies,6 operation-and-postoperative-chemotherapies.

CONCLUSIONS: KHE is a rarely invasive tumor which mainly occours in infants and children and alwanys with Kabasach-Merritt syndrome, the treatment of which is mainly surgery, glucocorticoid, vincristine and other drug treatment.

CLINICAL IMPLICATIONS: Kaposi hemangioendothelioma is very rare, especially those occurring in mediastinum which easily misdiagnosed as lymphoma and transfer of pulmonary malignant tumor due to the medical personnel’ insufficient understanding and the limitied conditions of root hospital. Therefore, when a tumor with Kabasach-Merritt syndrome is meeted in clinical, Kaposi hemangioendothelioma should be cosiderated and carry out pathological biopsy to clarify the diagnose then give treatment as soon as possible.

DISCLOSURE: The following authors have nothing to disclose: Chen Juan

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