Lung Cancer: Lung Cancer I |

An Optimal Method to Establish Non-small Cell Lung Cancer Model With Highly Brain Metastasis FREE TO VIEW

Yusheng Chen; Meie Yu; Xunwei Tu; Xian Lin; Hongru Li
Author and Funding Information

Fujian Provincial Hospital, Provincial Clinical Medical College, Fujian Medical University, Fuzhou City, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A293. doi:10.1016/j.chest.2016.02.305
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Establishing an experimental model which can meet the medical need for the study of the mechanisms of non-small cell lung cancer model with highly brain metastasis.

METHODS: In this study, the human lung adenocarcinoma cells PC-9 were injected into the left cardiac ventricle of nude mice to establish brain metastasis models. Four weeks after the injection, the nude mice were examined by SPET/CT, then the tissues and organs were harvested for histological examination.

RESULTS: It confirmed that the incidence of brain metastasis in this study was 100%.

CONCLUSIONS: Injecting the PC-9 cells into left ventricular can imitate the physiological and pathological processes for brain metastasis from lung cancer, and it is the easiest and the most efficient method to establish the experimental model.

CLINICAL IMPLICATIONS: We use the intracardiac injection method with the lung adenocarcinoma PC-9 cell line, a highly brain metastatic potency cell line, to establish a highly brain-specific brain metastasis model, this model may be helpful to the research about brain metastasis of lung cancer.

DISCLOSURE: The following authors have nothing to disclose: Yusheng Chen, Meie Yu, Xunwei Tu, Xian Lin, Hongru Li

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