Lung Cancer: Lung Cancer I |

Higher Expression of Mdig Related to miR-190 Overexpression in Lung Cancer Patients. FREE TO VIEW

Xiaoge Wang; Jiaying Sun, MD
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The Fourth Affiliated Hospital of China Medical University, Shenyang, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A290. doi:10.1016/j.chest.2016.02.302
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: mdig is a newly founded oncogene which may relate to arsenic induced carcinogenicity. This study is aim to detect the relationship between mdig and miR190 in human NSCLC lung tissues.

METHODS: 30 NSCLC patients were involved in this study. Total RNA was extracted from tumor (T) and surrounding non-cancerous tissues (N). Mdig mRNA was amplified by PCR and miR190 were by qPCR. mdig and miR190 expressions between tumor (T) and the non-cancerous tissues (N) were compared.

RESULTS: Tumor tissues expressed higher level of mdig and miR190 than surrounding normal tissues in these NSCLC cases. Correlation analysis indicated the positive correlated between the mdig and miR190.

CONCLUSIONS: The related changes of mdig and miR-190 suggested that mdig may play an important role in NSCLC through miR-190.

CLINICAL IMPLICATIONS: Former data presented the different prognosis of NSCLC patients with different mdig expression levels, but the mechanism remains unclear. This research revealed the positive relationship between mdig and miR190 expression, which will possible investigate a new treatment strategy for NSCLC.

DISCLOSURE: The following authors have nothing to disclose: Xiaoge Wang, Jiaying Sun

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