Lung Cancer: Lung Cancer I |

Impact of Chronic Obstructive Lung Disease on Postoperative Recurrence in Patients With Resected Non-small Cell Lung Cancer FREE TO VIEW

Guangliang Qiang, MD; Chaoyang Liang; Fei Xiao; Qiduo Yu; Huanshun Wen; Zhiyi Song; Yanchu Tian; Bin Shi; Yongqing Guo; Deruo Liu, MD
Author and Funding Information

China-Japan Friendship Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A288. doi:10.1016/j.chest.2016.02.300
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The purpose of this study was to determine whether the severity of chronic obstructive lung disease (COPD) affects long-term survival in non-small cell lung cancer (NSCLC) patients after surgical resection.

METHODS: A retrospective research was performed on 421 consecutive patients who had undergone lobectomy for NSCLC from January 2008 to June 2011. Classification of COPD severity was based on guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Characteristics among the three subgroups were compared and recurrence-free survivals were analyzed.

RESULTS: 172 patients were diagnosed with COPD (124 as GOLD-1, 46 as GOLD-2, and 2 as GOLD-3). The frequencies of recurrence were significantly higher in relation to higher COPD grades (P < 0.001). Recurrence-free survival at five years was 78.1%, 70.4%, and 46.4% in Non-COPD, mild COPD, and moderate/severe COPD groups, respectively (P < 0.001). In univariate analysis, age, gender, smoking history, COPD severity, tumor size, histology and pathological stage were associated with recurrence-free survival. Multivariate analyses showed that older age, male, moderate/severe COPD, and advanced stage were independent risk factors associated with recurrence-free survival.

CONCLUSIONS: NSCLC patients with COPD are at high risk for postoperative recurrence, and moderate/severe COPD is an independent unfavorable prognostic factor.

CLINICAL IMPLICATIONS: It can contribute to adequate selection of the appropriate individualized treatment. This study suggests that comprehensive therapeutic strategies are required to improve long-term outcomes of resectable lung cancer with moderate to severe COPD.

DISCLOSURE: The following authors have nothing to disclose: Guangliang Qiang, Chaoyang Liang, Fei Xiao, Qiduo Yu, Huanshun Wen, Zhiyi Song, Yanchu Tian, Bin Shi, Yongqing Guo, Deruo Liu

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