Lung Cancer: Lung Cancer: Imaging |

Preliminary Study on Combining Bioconductance Measurement With 18FDG-PET in Evaluation CT Detected Lung Lesion Suspicious for Lung Cancer FREE TO VIEW

Dawei Yang, MD; Jing Li; Xin Gong; Rex Yung; ChunXue Bai
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Zhongshan Hospital Fudan University, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A282. doi:10.1016/j.chest.2016.02.294
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SESSION TITLE: Lung Cancer: Imaging

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: In China, lung cancer is the leading cause of cancer mortality and causes huge amount of health burdens. Positron Emission-Tomography (PET) scanning is suggested to functional evaluation lung lesion with expense. This study is designed to prove combining computed bioconductance (CB) measurement with 18FDG-PET could improve the evaluating suspicious lung lesion found by CT.

METHODS: In this prospective analysis of a prospective trail enrolling 33 patients with lung CT and CB, 10 had concomitant PET performed. Of these 10 patients, 8 had a malignant diagnosis based on pathology and 2 had a benign diagnosis according to tissue biopsy. A composite CB result was generated from measuring multiple locations on the skin by BSP-E2-1000-A (Prolung Biotech Wuxi Co, Wuxi, China), with the result scored as either positive or negative dependent on a defined cut-off point.

RESULTS: PET results yielded 3 ‘indeterminate’ reading, and excluding these 3, PET had 67% sensitivity (4/6 true positives) and 100% specificity (1/1 true negatives). CB evaluation of the 7 PET determinate cases also yielded 67% sensitivity (4/6 true positives) and 100% specificity (1/1 true negatives). With all cases, CB results improved sensitivity to 75% sensitivity (6/8 true positives). Of note, 2 of 5 cancer indeterminate 18FDG-PET readings were less than 3 cm in diameter and these were correctly categorized by CB.

CONCLUSIONS: In this study of a pre-biopsy assessment of malignant probability in CT-detected lung lesion, combining PET with CB as a non-invasive risk-stratification technology could improve the diagnostic efficacy.

CLINICAL IMPLICATIONS: This study is designed to prove combining computed bioconductance (CB) measurement with 18FDG-PET could improve the evaluating suspicious lung lesion found by CT.

DISCLOSURE: The following authors have nothing to disclose: Dawei Yang, Jing Li, Xin Gong, Rex Yung, ChunXue Bai

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