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Lung Cancer: Lung Cancer: Genetics |

Personalized Therapy With Genetic Susceptibility to Advanced Non-small Cell Lung Cancer

Yinlou Yang, MD
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Affiliated Yuebei People's Hospital, Medical College of Shantou University, Shaoguan City, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A280. doi:10.1016/j.chest.2016.02.292
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SESSION TITLE: Lung Cancer: Genetics

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Advanced non-small cell lung cancer (NSCLC) therapy is individualized for each patient based on the molecular characterization under the guidance of evidence-based medicine, do not violate the basic principles of standardization of treatment, a reasonable first-line, second-line or third-line chemotherapy, biological targeting treatment. The impact of chemotherapy-related molecular markers include the tumor excision repair cross-complementation group 1 (ERCC1) the expression level of platinum-based drugs, ribonucleotide reductase regulatory factor 1 (RRM1) expression levels with gemcitabine, thymidylate synthase (TS) expression levels with the efficacy of the drug. impact of the biological efficacy of targeted drug-related molecular markers include the epidermal growth factor receptor (EGFR) mutation status, K- ras mutation status and ALK fusion gene in NSCLC signaling pathway as a target of drug efficacy

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