Lung Cancer: Lung Cancer: Genetics |

EGFR 19/21 Gene Mutation Staus in Female Patients With Lung Adenocarcinoma in Chinese FREE TO VIEW

Ying Xue, BA
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The Inner Mongolia Autonomous Region People's Hospital, Hohhot City, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A278. doi:10.1016/j.chest.2016.02.290
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SESSION TITLE: Lung Cancer: Genetics

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To study the status of EGFR 19/21 gene mutation and its correlation with clinical features in Chinese female patients with lung adenocarcinoma

METHODS: Retrospective analysis of 56 cases of pathological diagnosed with female lung adenocarcinoma patients specimens, the EGFR 19/21 gene mutations were analyzed with the amplification refractory mutation method provided by the EGFR mutation test kit and ARMS technologies. The following data was collected: the patients' characteristics (age, smoking status, stage and lymph node metastasis. The correlation between histological features and these 19/21 gene mutations were evaluated using SPSS20.

RESULTS: In the 56 cases of female lung adenocarcinoma cases, Mutations of EGFR were detected in 51.8% (29/56) of lung adenocarcinomas;19del and L858R were major mutational types (89.6%,26/29). EGFR mutations were associated with non-smoking status, and well to moderately differentiated tumor histology. EGFR mutation types were not associated with age, lymph node metastasis, and stage. In addition exon19 del gene mutation was more frequent compared with L858R on exon21 gene in female lung adenocarcinomas (65.3%.versus 34.6%, p=0.034).

CONCLUSIONS: The EGFR gene mutations were related to clinical features in Chinese patients with lung adenocarcinoma of female. Exon19 del gene mutation was more prevalent in Chinese female lung adenocarcinoma.

CLINICAL IMPLICATIONS: Exon19 del gene mutation was more frequent in Chinese female lung adenocarcinoma. Some studies show this gene mutation in lung adenocarcinoma is more effective to TKI Treatment and has a good prognosis. Of course our study is confined to a small sample. We need more research to support this result.

DISCLOSURE: The following authors have nothing to disclose: Ying Xue

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