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Lung Cancer: Lung Cancer: Genetics |

Impact of Ethnicity on the Initial Incidence of Brain Metastasis in Patients With EGFR-Mutant Lung Cancer

Jiexia Zhang, MD; Jianxing He, MD
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Guangzhou Respiratory Institute, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A276. doi:10.1016/j.chest.2016.02.288
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SESSION TITLE: Lung Cancer: Genetics

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The objective of this study was to determine the incidence of brain metastasis at initial diagnosis in East Asian and Caucasian patients with EGFR-mutant lung cancer.

METHODS: Descriptive statistics were generated for demographics, smoking habits, histology, and EGFR mutation subtypes, stratified by status of brain metastasis at diagnosis. Chi-squared tests and t-tests were used for testing associations of categorical variables and continuous variables with brain metastasis at diagnosis, respectively. Logistic regression models were used to study the association between race and brain metastasis at diagnosis, with and without adjusting for age at initial diagnosis, gender, EGFR mutation type, smoking status, and histology. Odds ratio (OR) and corresponding 95% confidence intervals (CI) were obtained. All analyses were two sided and a p value <0.05 were considered significant.

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