Lung Cancer: Lung Cancer: Diagnosis and Prognosis |

Association of Preoperative Neutrophil-to-Lymphocyte Ratio With Clinicopathological Characteristics and Prognosis in Stage I Non-small Cell Lung Cancer FREE TO VIEW

Guangliang Qiang, MD; Chaoyang Liang; Qiduo Yu; Fei Xiao; Huanshun Wen; Zhiyi Song; Yanchu Tian; Bin Shi; Yongqing Guo; Deruo Liu
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China-Japan Friendship Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A272. doi:10.1016/j.chest.2016.02.284
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SESSION TITLE: Lung Cancer: Diagnosis and Prognosis

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 09:45 AM - 11:15 AM

PURPOSE: To investigate the correlation between preoperative neutrophil-to-lymphocyte ratio (NLR) and clinicopathological features, as well as the prognostic impact of NLR in patients with stage I non-small cell lung cancer (NSCLC) after complete surgical resection.

METHODS: A total of 567 patients who underwent complete resection of stage I NSCLC in our institution from May 2007 to May 2014 were analyzed retrospectively. According to median value of peripheral blood NLR, study population was divided into two groups. The correlation between NLR and clinicopathological features was investigated. Univariate and multivariate survival analyses were performed to assess the prognostic value of preoperative NLR.

RESULTS: The median value of NLR was 2.19 (range: 0.48 to 47.25). The 5-year overall survival (OS) of the patients with a high NLR was significantly worse than those with a low NLR (75.7% vs. 87.3%, p=0.004). Univariate analysis of the clinicopathological factors revealed that age, gender, smoking history, histology, tumor size, lymphovascular invasion (LVI), visceral pleural invasion (VPI), and NLR were significant risk factors associated with survival. On multivariate Cox regression analysis, age, gender, tumor size, LVI, VPL, and NLR were independent risk factors of prognosis.

CONCLUSIONS: Preoperative NLR is an independent prognostic biomarker in patients with stage I NSCLC, an elevated NLR indicates poor prognosis.

CLINICAL IMPLICATIONS: The NLR is a potential biomarker to influence patient selection in this regard because it is almost universally available and adds no additional cost to routine preoperative workup in comparison with more sophisticated and expensive technologies.

DISCLOSURE: The following authors have nothing to disclose: Guangliang Qiang, Chaoyang Liang, Qiduo Yu, Fei Xiao, Huanshun Wen, Zhiyi Song, Yanchu Tian, Bin Shi, Yongqing Guo, Deruo Liu

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