Lung Cancer: Lung Cancer: Diagnosis and Prognosis |

Clinical Characteristics and Survival of Patients With Multiple Primary Malignancies Involving Lung Cancer FREE TO VIEW

Fengying Wu; Shan Shan; Tao Ren
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Shanghai Pulmonary Hospital Tongji, University School of Medicine, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A271. doi:10.1016/j.chest.2016.02.283
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SESSION TITLE: Lung Cancer: Diagnosis and Prognosis

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 09:45 AM - 11:15 AM

PURPOSE: To investigate the characteristics and survival of lung cancer patients with additional malignant primaries.

METHODS: Records of lung cancer patients diagnosed in Shanghai Pulmonary Hospital between January 2000 and January 2010 were retrospectively reviewed. Patients harboring additional primaries before diagnosis of lung cancer and those with single lung cancer diagnosis were included for detailed analysis.

RESULTS: Of 27642 newly diagnosed lung cancer patients, 283 patients (1.02%) harboring additional primaries. Compared with single primary lung cancer, patients with multiple primaries were more often women (female to male ratio of 1:1.72 vs 1:2.59, P=0.018) and older (64.2 vs 60.5 years, P<0.001), more squamous cell type (30.7% vs 20.7%, P=0.004) and less small cell (3.9% vs 20.7%, P<0.001) type, present at earlier stages (17.7% vs 10.9% for stage I, P=0.014), and more frequently have a family history of cancer (7.8% vs 3.9%, P=0.038). The most common primaries observed were cancers of colorectal (22.0%), breast (18.4%), gastric (14.4%) and larynx (11.9%). Approximately 42.9% of lung cancers were found 2 to 6 years after initial primaries. The survival of patients with multiple primary malignancies associated lung cancer is not significantly different from those with single lung cancer diagnosis (P=0.491), while synchronous multiple primary malignancies have obviously worse prognosis than those with metachronous or single ones (p=0.012).

CONCLUSIONS: The possibility of a second primary lung cancer should always be considered during the follow-up of most related cancer types, especially those having a family history. Multiple primary malignancies involved lung cancer patients have non-inferior survival than those with single lung cancer diagnosis.

CLINICAL IMPLICATIONS: Investigation of MPMs could help us to further understand risk factors for a second primary cancer

DISCLOSURE: The following authors have nothing to disclose: Fengying Wu, Shan Shan, Tao Ren

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