CASE PRESENTATION: 67 year-old female, retired teacher. Former smoker (30 years/pack) with asthma since childhood, started in August 2010 with fatigue, dyspnea mMRC 2, persistent cough and heartburn. Clinical examination:regular general condition, acyanotic, wheezing in lower left third, no clubbing. GERD diagnosed by pH monitoring. Normal spirometry. Chest x-ray, chest tomography and PET CT show retrocardiac soft tissue lesion measuring 7cm in major axis. Systemic cancer staging with no abnormalities. Computarized Tomography (CT) guided biopsy obtained a sample which immunohistochemistry confirmed mucosa-associated lymphoid tissue (MALT) lymphomas. Treated with chemotherapy performed with R-CVP protocol for 6 cycles had no adverse events. Cough progressively disappeared. Currently asymptomatic with normal chest PETCT and CT.