Lung Cancer: Late-Breaking Abstracts: Lung Cancer Mechanisms |

Detection of FHIT in Non-small Cell Lung Carcinomas: Correlation With Clinicopathologic Parameters FREE TO VIEW

Ioannis Sfiniadakis, MD; Evdokia Sfiniadaki, MDS; Dimitra Vasileiou-Dervisoglou, MD; Fotios Psarros, MD; Ekaterini Politi, MD
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Athens Naval Hospital, Keratsini, Greece

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A259. doi:10.1016/j.chest.2016.02.271
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SESSION TITLE: Late-Breaking Abstracts: Lung Cancer Mechanisms

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 08:30 AM - 09:30 AM

PURPOSE: The purpose of this study is the expression of FHIT in non small cell lung carcinomas and its relationship with clinicopathologic parameters.

METHODS: We studied tissue sections of 84 patients, 48 - 81 years old (mean age 62.3 years) from the file of Surgical Pathology Department of Athens Naval Hospital with primary non small cell lung carcinoma (44 squamous cell carcinomas, 40 adenocarcinomas, 50 smokers, 34 non smokers). We used the immunohistochemical method avidin-biotin-peroxidase after the pretreatement of the slides in microwave with citrate buffer 10mmol / L, ph:6.0. The polyclonal antibody anti-FHIT 1: 50 dilution was used (incubation time 1 hour in room temperature)

RESULTS: The results of FHIT expression in correlation with the type of tumor was Squamous cell carcinomas positive: 9/44 (21.5%), negative 35/44 (79.5%) Adenocarcinomas: positive: 36/40 (90%), negative 4/40 (10%) The results of FHIT expression in correlation with smoking habits Smokers: positive: 12/50 (24%) negative:38/50(76%) Non smokers: positive: 33/34 (97.06%) negative: 1/34 (2.94%) The results of FHIT expression in correlation with tumor differentiation Low grade differentiation: positive: 20/46 (43.48%) negative:26/46(56.52%) Medium & high grade differentiation: positive:25/38 (65.79%) negative: 13/38 (34.21%) It was observed: 1. A significant decrease in the expression of FHIT in squamous carcinomas compared to adenocarcinomas (p <0.001) 2. Greater frequency of loss of the FHIT’s expression in smokers (p <0.001) 3. Larger reduction of the expression of FHIT in low grade differentiation tumors compared to these of high and middle differentiation (p = 0.017)

CONCLUSIONS: There is a differentiation of the expression of FHIT between histological types of lung carcinomas Exposure to tobacco carcinogens probably is the cause of distortion of the specific oncogene Inactivation of FHIT is an important step in the process of carcinogenesis in lungs.

CLINICAL IMPLICATIONS: We could use it as a predictor factor and probably we could modify the FHIT gene to prevent lung's carcinogenesis

DISCLOSURE: The following authors have nothing to disclose: Ioannis Sfiniadakis, Evdokia Sfiniadaki, Dimitra Vasileiou-Dervisoglou, Fotios Psarros, Ekaterini Politi

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