METHODS: Lung adenocarcinoma A549 cells were subcutaneously injected into 30 male BALB/c nude mice, building a xenograft model. The mice were divided into 4 groups as follows: control, imrecoxib, lobaplatin, and imrecoxib combined with lobaplatin (combined). Tumor volumes were measured each week. The mice were sacrificed after 6.0 weeks and the xenograft tissues were removed. Hematoxylin and eosin staining was used to observe any pathological changes in tumor tissues in each group. Real-time polymerase chain reaction, immunohistochemistry, and flow cytometry were used to detect tumor ezrin and cortactin mRNA and their protein expression levels. The statistics were analyzed by one-way analysis of variance or non-parametric tests.