RESULTS: The two patients were sisters of an inbred family whose parents were cousins and presented typical manifestation of recurrent cough, progressive dyspnea. High resolution computed tomography (HRCT) demonstrated the pulmonary was full of high density reflection of intraalveolar microliths especially in double lower lobe, and calcification was found in the pericardial, aorta and pleural. Pulmonary function showed impairment of small airway and dispersion function. Pathology of lung biopsy showed irregular microlith with lamination and massive calcification by hematoxylin-eosin (HE) stain. We found heterozygous mutation of the SLC34A2 gene, c.910A > T (p.K304X) in exon 8 in the consanguineous marriage of parents and homozygous mutation in two patients.