Genetic and Developmental Disorders: Genetic Disorders |

The Association of Tumor Necrosis Factor Alpha Gene Polymorphisms -308G/A and -238G/A With Asthma Risk: A Meta-analysis Including 6672 Cases and 6681 Controls FREE TO VIEW

Jianquan Zhang; Hui Zhang; Siqiao Liang
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The First Affiliated Hospital of Guangxi Medical University, Nanning, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A247. doi:10.1016/j.chest.2016.02.257
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SESSION TITLE: Genetic Disorders

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Several studies have evaluated the association between the tumor necrosis factor alpha gene (TNF-α) −308G/A and −238G/A polymorphisms and asthma, but the findings are inconclusive. This study therefore performed a meta-analysis as a more comprehensive investigation of the association between TNF-α polymorphisms and asthma.

METHODS: We systematically searched for relevant articles about TNF-α polymorphisms and asthma risk in the PubMed database, Wanfang database, China National Knowledge Infrastructure, and Weipu database. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations.

RESULTS: A total of 40 case-control studies from 38 articles were included in the meta-analysis, including 6,672 cases and 6,681 controls for TNF-α −308G/A, and 972 cases and 977 controls for TNF-α −238G/A. The −308G/A polymorphism was associated with a significantly increased risk of asthma when all studies were pooled in a AA +GA vs. GG model (OR=1.497, 95%CI=1.245-1.798, p<0.001, I2=65.5%), AA vs. GG model (OR=1.819, 95%CI=1.354-2.444, p<0.001, I2=17.7%), and A vs. G model (OR=1.406, 95%CI=1.201-1.646, p<0.001, I2=66.8%), but not in AA vs. GA+GG. The cumulative meta-analysis and sensitivity analysis further strengthened the stability of our result. However, no significant association between the −238G/A polymorphism and asthma risk was found in any gene models.

CONCLUSIONS: The TNF-α −308G/A, but not the −238G/A, polymorphism appears to be associated with an increased asthma risk.

CLINICAL IMPLICATIONS: The TNF-α −308G/A, but not the −238G/A, polymorphism appears to be associated with an increased asthma risk.

DISCLOSURE: The following authors have nothing to disclose: Jianquan Zhang, Hui Zhang, Siqiao Liang

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