Genetic and Developmental Disorders: Genetic Disorders |

Association of ADAM33 Gene Polymorphisms With Chronic Obstructive Pulmonary Disease in Han Population of Northern China FREE TO VIEW

Ruijun Qin; Ping Wang
Author and Funding Information

Taiyuan City Central Hospital, Taiyuan, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A246. doi:10.1016/j.chest.2016.02.256
Text Size: A A A
Published online

SESSION TITLE: Genetic Disorders

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate whether polymorphisms and haplotypes in ADAM33 gene are associated with chronic obstructive pulmonary disease (COPD) and lung function in Han population of northern China.

METHODS: The genotypes of S1, S2, BC+1, F+1, M + 1 and Q1 locus alleles in 100 COPD patients and 100 healthy controls were tested with PCR-direct sequeneing analysis. Haplotypes and their frequencies were established and analyzed by SHEsis online software.

RESULTS: 1. there were significant differences between the COPD group and the control group in the frequencies of S2, F+1, Q1 locus genotypes and alleles (P<0.05). 2. In COPD group, the relationship between ADAM33 gene S2, F+1 locus genotypes and clinical parameters of lung function display: the difference of FEV1% in genotypes was no statistically significant, but the difference of FEV1/FVC in genotypes was statistically significant.

CONCLUSIONS: In Han population of northern China, the polymorphisms and haplotypes in ADAM33 gene have association with the susceptibility to COPD, and have no association with the severity of COPD.

CLINICAL IMPLICATIONS: Asthma and chronic obstructive pulmonary disease (COPD) are chronic airway inflammatory disease. Although there are many differences from pathogenesis to clinical manifestations, a growing number of studies have shown that both have many similarities in the etiology, pathogenesis and clinical manifestations. a disintegrin and metalloprotease 33 (ADAM33) gene as the first asthma susceptibility gene, identified by positional cloning, has been confirmed that are associated with the development and course of COPD. So ADAM33 gene may be the bridge of asthma and COPD in pathogenesis.

DISCLOSURE: The following authors have nothing to disclose: Ruijun Qin, Ping Wang

No Product/Research Disclosure Information




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543