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Diffuse Lung Disease: Diffuse Lung Disease: Sarcoidosis |

Repeated Challenge With Propionibacterium Acnes-Induced Chronic Sarcoidosis With Pulmonary Fibrosis in C57BL/6 Mice

Dingyuan Jiang; Huaping Dai, MD; Xiaoxi Huang
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Beijing Chao-Yang Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A221. doi:10.1016/j.chest.2016.02.228
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SESSION TITLE: Diffuse Lung Disease: Sarcoidosis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chronic sarcoidosis associated pulmonary fibrosis (PF) has a negative impact on mortality, which was poorly understood and lack of experimental model. Previous studies showed self-remission granuloma in Propionibacterium acnes (PA)-boost mice. Gene expression researches suggested that fibrosis developed from sarcoidosis in the setting of inflammation. We investigated whether consistent inflammation induced by repeat boost with PA will lead to PF following sarcoidosis in mice.

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