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Diffuse Lung Disease: Diffuse Lung Disease: Interstitial Lung Disease |

The Expression and Role of IL-25 and Its Receptor in Idiopathic Pulmonary Fibrosis

Xuefeng Xu, MD; Jing Geng, MD; Shuhong Li; Dingyuan Jiang, MD; Chen Wang, MD; Huaping Dai, MD
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Beijing Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A213. doi:10.1016/j.chest.2016.02.220
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SESSION TITLE: Diffuse Lung Disease: Interstitial Lung Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Idiopathic pulmonary fibrosis (IPF) is a lethal disease with no proven drug treatment for blocking or reversing the decline of lung function. It is now believed that chronic injury of alveolar epithelial cells initiates IPF. Recent studies showed that IL-25, derived from the disregulated lung epithelial cells, can induce airway inflammation and remodeling which mimics human asthma. Thus, we aim to examine the expression of IL-25 and its receptor (IL-17RB/RA) in IPF lung tissues and their potential roles in regulating the pathogenesis of IPF.

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