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Diffuse Lung Disease: Diffuse Lung Disease: Interstitial Lung Disease |

Erythropoietin Inhibits the Immunohistochemical Expression of Lysyl Oxidase in Bleomycin-Induced Pulmonary Fibrosis in Rats

Drosos Tsavlis, PhD; Sofia Tsirona, MD; Fotios Katsaros, MD; Anastasia Tektonidou, MMSc; Anna Tzoumaka, MD
Author and Funding Information

Aristotle University of Thessaloniki, Thessaloniki, Greece


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A211. doi:10.1016/j.chest.2016.02.218
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SESSION TITLE: Diffuse Lung Disease: Interstitial Lung Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Pulmonary Fibrosis (PF) is characterized by fibroblasts' proliferation, excessive deposition of collagen and extracellular matrix remodelling. The enzyme Lysyl Oxidase (LOX) is well known for its important role in the fibrotic pathway with inflammatory and apoptotic actions. Erythropoietin (EPO), on the other hand, is a multiple functional cytokine with anti-inflammatory and anti-apoptotic properties. The purpose of this study was to investigate the role of EPO on the immunohistochemical expression of LOX in Bleomycin (BLM)-induced PF in rats.

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