Diffuse Lung Disease: Diffuse Lung Disease: Connective Tissue Disease |

Electromyography in Newly-Diagnosed Systemic Connective Tissue Disease-Associated Interstitial Lung Disease FREE TO VIEW

Zheng Wang, MD; Xiaoju Zhang, MD; Lijun Ma, MD
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Henan Provincial People's Hospital, Zhengzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A207. doi:10.1016/j.chest.2016.02.214
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SESSION TITLE: Diffuse Lung Disease: Connective Tissue Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: This prospective study was to evaluate the changes of electromyography (EMG) in systemic connective tissue disease-associated interstitial lung disease (CTD-ILD).

METHODS: Patients that were newly diagnosed with CTD-ILD were screened with EMG. The damage were classified as neurogenic, myogenic or mixed, each was graded as mild, moderate and severe. Lung function and clinical data were collected using questionnaires. The fibrosis score by high-resolution CT scanning were evaluated by two separate radiologists.

RESULTS: We examined 100 CTD-ILD patients, 44 (44%) are presented with EMG abnormalities, 7 neurogenic, 23 myogenic and 14 were mixed. EMG abnormalities were identified in: 6/24 with ANCA-associated vasculitis, 5/21 with rheumatoid arthritis (RA), 6/17 with primary Sjogren's disease (PSS), 12/13 with polymyositis/dermatomyositis (PM/DM), 6/8 with undifferentiated connective tissue disease (UD-CTD), 4/6 with mixed CTD (MCTD), 2/6 with systemic lupus erythematosus (SLE), 3/5 with scleroderma. Myogenic abnormalities were most common in PM/DM, while mixed EMG abnormalities were most common in MCTD. There were no statistical differences in patients with or without EMG abnormalities in age, sex, lung fibrosis score and blood gas, but patients with EMG abnormalities had a poorer performance in 6MWT [ (320.8±63.5) m vs 357.5±78.8) m], FVC [ (43.5±8.6) % vs 51.3±10.6) % of predicted] and DLco [ (38.2±12.4) % vs 45.7±14.8) %] than those without (all P<0.05).

CONCLUSIONS: EMG abnormalities are common in CTD-ILD, and may be associated with impaired physical activities and lung function.

CLINICAL IMPLICATIONS: Electromyography (EMG) abnormalities are common in CTD-ILD, which is associated with impaired physical activities and lung function. Routine EMG test might serve as a routine for CTD-ILD.

DISCLOSURE: The following authors have nothing to disclose: Zheng Wang, Xiaoju Zhang, Lijun Ma

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