Diffuse Lung Disease: Diffuse Lung Disease: Connective Tissue Disease |

Clinical Characteristics of Connective Tissue Disease-Associated Interstitial Lung Disease in 1,044 Chinese Patients FREE TO VIEW

Yang Hu, PhD; Liusheng Wang; Yaru Wei; Shanshan Du; Yukui Du; Xian He; Nan Li; Ying Zhou; Qiuhong Li; Yiliang Su; Fen Zhang; Li Shen; Huiping Li, PhD; Kevin Brown, MD; Dong Weng, PhD
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Medicine Shanghai Pulmonary Hospital Tongji University, School of Medicine, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A206. doi:10.1016/j.chest.2016.02.213
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SESSION TITLE: Diffuse Lung Disease: Connective Tissue Disease

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To analyze the clinical characteristics of connective tissue disease- associated interstitial lung disease (CTD-ILD) in Chinese patients.

METHODS: The medical records of patients diagnosed with ILD and treated in our hospital from January 1999 to January 2013 were reviewed. From the records, patients who were also diagnosed with CTD were identified and their records of follow-up examinations for a minimum of 12 months till the end of December 2013 were reviewed.

RESULTS: Of the 2678 patients diagnosed with ILD, 1798 (67%) were identified as CTD-ILD; 299 (11.2%) had idiopathic pulmonary fibrosis (IPF). Complete clinical data were available from 1044 patients with CTD-ILD and 178 patients with IPF. We found that 32% of the 1044 patients with CTD-ILD were not diagnosed accurately at the initial hospital admission; 19% showed persistent negative test results for autoantibodies; 25% had negative autoantibodies at initial hospital admission and then became positive at follow-up examinations. Of the 288 patients with confirmed CTD-ILD, 14% showed pulmonary symptoms as the initial clinical manifestation (PSIM) and 86% showed extra-pulmonary symptoms as the initial clinical manifestation (EPSIM). Of the 756 patients with undifferentiated CTD-ILD, the proportion of PSIM and EPSIM were 44% and 56%, respectively.

CONCLUSIONS: Patients with CTD-ILD are not diagnosed accurately at the initial hospital admission possibly because of negative serologic test results for autoantibodies and absence of obvious extra-pulmonary symptoms.

CLINICAL IMPLICATIONS: Thus, patients with ILD should be examined for extra-pulmonary symptoms and tested for autoantibodies at follow-up examinations.

DISCLOSURE: The following authors have nothing to disclose: Yang Hu, Liusheng Wang, Yaru Wei, Shanshan Du, Yukui Du, Xian He, Nan Li, Ying Zhou, Qiuhong Li, Yiliang Su, Fen Zhang, Li Shen, Huiping Li, Kevin Brown, Dong Weng

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