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Diffuse Lung Disease: Diffuse Lung Disease |

Sarcoid-Like Reaction After Treatment With Ipilimumab

Klaus Meinhof, MD; Timothy Harkin, MD; Sidney Braman, MD
Author and Funding Information

Mount Sinai Medical Center, New York, NY


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A201. doi:10.1016/j.chest.2016.02.208
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SESSION TITLE: Diffuse Lung Disease

SESSION TYPE: Case Report Poster

PRESENTED ON: Sunday, April 17, 2016 at 11:45 AM - 12:45 PM

INTRODUCTION: It has been discovered that the immune system can recognize, and in some cases control tumor growth. Enhancing T-cell activation is a potent way to amplify anti-tumor immune responses. Ipilimumab is an antibody that blocks the co-inhibitory receptor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) that functions to attenuate T-cell responses. The drug has been shown to be an effective agent in the treatment of metastatic melanoma. A variety of toxicities have been described, most commonly enterocolitis, hepatitis and skin rashes. We describe a case of Ipilimumab induced lung toxicity.

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