DISCUSSION: There are no cases describing COP and PC occurring in CD meanwhile1. In our present case, the clinical symptoms, the CT scan abnormalities, the lung histology, the clinical course and the response to corticosteroid treatment were strongly suggestive of COP. Nevertheless, it is important for us to know that COP may be caused by drugs employed in the treatment of CD, such as mesalazine and azathioprine2. What’s more, it is generally accepted that opportunistic infections in CD such as PC3, often occur in patients who are under the treatment of immunosuppressive medications. The patient had no symptoms or imaging manifestations of PC. So whether fluconazole should be given became a dilemma.