RESULTS: We Identified 7071 patients with severe sepsis, 1573 of whom had septic shock. The overall mortality was 7.0%. The mean number of ODS was 2.63 ± 1.27 (mean ± STDEV). The most common ODS was the bone marrow (67%), and the least common site was the CNS (0.93%). Cardiovascular dysfunction was associated with the highest mortality (26.2%), longest LOS (14.3 ± 15.2 days), and highest rate of ICU admission (74.7%). CNS dysfunction had the lowest mortality rate (6.1%), the second highest ICU admission rate (57.6%), and the highest rate of readmission within 30 days (28.8%). Increased number of ODS positively correlated with hospital LOS (R=0.99, p<.001) and ICU LOS (R=0.91, p<.001). No significant difference in mortality, ICU admission rate, or 30 day readmission was seen in patients with ≤2 ODS vs those who had no ODS. However, the odds of death increased with each additional ODS when there were ≥4 ODS involved, 4 ODS (OR=9.08, 95% CI: 2.21-37.3) and 7 ODS (OR=46.7, 95% CI,:10.42 - 209.62). The odds of ICU admission (3 ODS (OR=21.87 95% CI:1.91-4.89)) and 30 day readmission (4 ODS (OR=6.03, 95% CI:1.13-3.12)) also increased with addtional ODS vs those without ODS.