SESSION TITLE: Mechanisms of Lung Injury
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM
PURPOSE: Vitamin D-binding protein (VDBP), known as group-specific component globulin (Gc-globulin), is a multi-functional plasma protein with many important functions such as transport of vitamin D and modulates immune and inflammatory responses via a macrophage-activating factor (known as Gc-globulin-MAF through partial deglycosylation. In this study, we investigated the effect of LPS-induced apoptosis in RAW 264.7 macrophages with the over-expression of Vitamin D-binding proteinand the underlying intracellular signal transduction pathways.