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Critical Care: Mechanisms of Lung Injury |

Mitogen-Activated Protein Kinase Pathway Mediates LPS-Induced Apoptosis in RAW 264.7 Macrophages With the Over-Expression of Vitamin D-Binding Protein

Duchao Zhang; Lixin Xie
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Chinese PLA General Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A185. doi:10.1016/j.chest.2016.02.191
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SESSION TITLE: Mechanisms of Lung Injury

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM

PURPOSE: Vitamin D-binding protein (VDBP), known as group-specific component globulin (Gc-globulin), is a multi-functional plasma protein with many important functions such as transport of vitamin D and modulates immune and inflammatory responses via a macrophage-activating factor (known as Gc-globulin-MAF through partial deglycosylation. In this study, we investigated the effect of LPS-induced apoptosis in RAW 264.7 macrophages with the over-expression of Vitamin D-binding proteinand the underlying intracellular signal transduction pathways.

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