SESSION TITLE: Mechanisms of Lung Injury
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM
PURPOSE: Mechanistic target of rapamycin (mTOR) plays a crucial role in many major cellular processes including cellular metabolism, proliferation and autophagy induction, and is also implicated in a growing number of proliferative and metabolic diseases. Both mTOR and autophagy have been suggested to be involved in the regulation of acute lung injury (ALI). Epithelium, being a key component of respiratory tract defence, plays a key role in both the pathogenesis and resolution of ALI. However, little is known about the role of mTOR and autophagy in pulmonary epithelium in the context of ALI.