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Critical Care: Mechanisms of Lung Injury |

Dysregulation of mTOR and Autophagy in Pulmonary Epithelium Participates in LPS-Induced Acute Lung Injury

Yue Hu, PhD; Yuanyuan Mao, MS; Jian Lou, PhD; Tianwen Lai, PhD; Chen Zhu, PhD; Liyao Liu, MS; Chao Zhang, PhD; Juan Liu, MS; Songmin Ying, PhD; Wen Li, PhD; Zhihua Chen, PhD; Huahao Shen, PhD
Author and Funding Information

Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A184. doi:10.1016/j.chest.2016.02.190
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SESSION TITLE: Mechanisms of Lung Injury

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM

PURPOSE: Mechanistic target of rapamycin (mTOR) plays a crucial role in many major cellular processes including cellular metabolism, proliferation and autophagy induction, and is also implicated in a growing number of proliferative and metabolic diseases. Both mTOR and autophagy have been suggested to be involved in the regulation of acute lung injury (ALI). Epithelium, being a key component of respiratory tract defence, plays a key role in both the pathogenesis and resolution of ALI. However, little is known about the role of mTOR and autophagy in pulmonary epithelium in the context of ALI.

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