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Critical Care: Mechanisms of Lung Injury |

Protective Effects and Mechanisms of Suppressing STAT3 Pathway on LPS-Induced Acute Lung Injury

Liang Dong
Author and Funding Information

Qilu Hospital of Shandong University, Jinan, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A183. doi:10.1016/j.chest.2016.02.189
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SESSION TITLE: Mechanisms of Lung Injury

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM

PURPOSE: Acute lung injury (ALI), the basis of acute respiratory distress syndrome (ARDS) is a critically clinic syndrome with high morbidity and mortality in intensive care units (ICU). Currently, there is no effective pharmacological treatment for acute lung injury. STAT3 signaling pathway plays a crucial role in the inflammation process of acute lung injury (ALI). This study aimed to investigate the protective effect of LLL12, an inhibitor of STAT3, and SOCS3, a negative regulator of STAT3, on LPS-induced ALI.

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