SESSION TITLE: Mechanisms of Lung Injury
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Saturday, April 16, 2016 at 04:00 PM - 05:00 PM
PURPOSE: Acute lung injury (ALI), the basis of acute respiratory distress syndrome (ARDS) is a critically clinic syndrome with high morbidity and mortality in intensive care units (ICU). Currently, there is no effective pharmacological treatment for acute lung injury. STAT3 signaling pathway plays a crucial role in the inflammation process of acute lung injury (ALI). This study aimed to investigate the protective effect of LLL12, an inhibitor of STAT3, and SOCS3, a negative regulator of STAT3, on LPS-induced ALI.