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Critical Care: Mechanisms of Infections |

Clinical and Experimental Significance of Vitamin D-Binding Protein in Patients With Sepsis and the Mouse Sepsis Model

Duchao Zhang, PhD; Kun Xiao, MD; Wei Guan; LongXiang Su; Lixin Xie
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Chinese PLA General Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A181. doi:10.1016/j.chest.2016.02.187
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SESSION TITLE: Mechanisms of Infections

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 04:00 PM - 05:00 PM

PURPOSE: In this study, we sought to determine the correlation between the degree of serum VDBP and progression of sepsis patients and mouse sepsis model.

METHODS: We performed a prospective study on 131 patients diagnosed with sepsis at different stages (sepsis group) and 25 patients with severe acute pancreatitis (control groups). A classic caecal ligation and puncture (CLP) in comparison with a sham procedure was used to establish experimental sepsis model in mice (n=40). Serum VDBP levels were assayed by ELISA. The pathologic changes were observed under electron microscope via HE stain. To measure the optical density of VDBP immunoreactivity, the region of interest in the lung, liver and spleen of mice were acquired.

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