RESULTS: We collected 102 molecules of known terpenoids with 768 stereo structure from Houttuynia Cordata. After ligand profiler, about 71,500 pharmacophores were hit, including 854 proteins. After CDOCKER, 260 proteins were filtered out as potential targets. Finally, we find that the potential targets are hydrolases (especial PDE, coagulation factor, rennin and methionine aminopeptidase), cell cycle proteins (especial cell division protein kinase 2, kinesin-like protein kif11 and MDM4 protein), chaperone (hsp), cell adhesion protein (integrin α), hormone receptor (progesterone receptor), gene regulation proteins (PPARγ), glutathione reductase. In addition, the terpenoids could also bind with the myosin in Dictyostelium discoideum, β-lactamase TEM and β-glucuronidase in E. coli, β-cryptogein in Phytophthora Cryptogea, cell invasion protein in Salmonella Enteric and replicase polyprotein 1ab in SARS coronavirus.