RESULTS: There were 7071 cases of severe sepsis/septic shock, 3400 (48%) women and 3671 (52%) men, aged 59.7 ± 16.1 (mean ± SD) years. Overall mortality was 7.0%, while septic shock mortality was 20.9%. Among these patients, the average number of comorbidities was 4.28 ± 2.0. The most common documented comorbidity was hypertension (56.2% of encounters) and the least common was peptic ulcer disease (0.04%). Mortality for patients with no comorbidities was 2.4%. Metastatic cancer was associated with the highest mortality (17.4%). Between patients with 0 and 1-3 comorbidities, no significant difference was seen in mortality. However, among patients with ≥4 comorbidites, the odds of death was elevated with each increase in number of comorbidities (4 (OR=3.48, 95% CI:1.09-11.1) or ≥5 (OR=3.5, 95% CI:1.10-11.0). Among patients with ≥4 comorbidites, the odds of being readmitted within 30 days was higher than those without without any comorbidites (OR=1.6, 95% CI:1.008-2.54).