Critical Care: Critical Care: Sepsis |

Plasma Calreticulin Expression Is a Predictor of Mortality in Septic Patients FREE TO VIEW

Yongbo Huang, MD; Yuanyuan Yang; Yimin Li, MD; Pu Mao, PhD
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Guangzhou Institute of Respiratory Disease, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A167. doi:10.1016/j.chest.2016.02.173
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SESSION TITLE: Critical Care: Sepsis

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Regulation of the immune cell apoptosis has recently considered as a novel therapeutic approach for sepsis. Calreticulin is reported to involve in cell apoptosis. However, little is known about the Calreticulin level in sepsis patients. The objective of this study is to explore the association between Calreticulin level and outcomes in septic patients.

METHODS: We performed a retrospective analysis of 127 septic patients in Intensive Care Unit (ICU) of Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, from October 2012 to May 2015. Calreticulin measurement as well as he demographic, APACHE II score, biochemical parameters were recorded on day 1. The length of stay in ICU and the outcome of the 127 septic patients were recorded.

RESULTS: Calreticulin value was a good predictor of all-cause 28 days mortality in septic patients. The level of plasma Calreticulin was significantly higher in non survivors compared to that of survivors (0.899 (0.354-4.503) vs.0.333 (0.107-1.290) ng/ml; p=0.03). Those patients with calreticulin levels <0.3435 ng/ml showed higher cumulative survival than those with level greater than or equal to 0.3435 ng/ml (83.6% vs. 56.9%, p = 0.01).

CONCLUSIONS: Calreticulin value measured at the time of admission to the ICU is a predictor of short-term mortality. The increased Calreticulin could serve as a poor prognosis factor of patients with sepsis.

CLINICAL IMPLICATIONS: Calreticulin has the potential clinical utility to predict outcome in septic patients.

DISCLOSURE: The following authors have nothing to disclose: Yongbo Huang, Yuanyuan Yang, Yimin Li, Pu Mao

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