RESULTS: Total of 63 ARDS patients had been identified. Among them, 27 had been dead within 28-day follow-up. The plasma galectin- 3 level of them was significantly higher than control group (median (IQR) 12.37 (7.94-18.79) versus 5.01 (4.15-5.69) ng/mL, P< 0.0001). Furthermore, it was significantly higher in nonsurvivors group than others (10.07 (7.39-15.54) vs. 15.38 (11.59-22.98) ng/mL, P = 0.0136). The level of galectin-3 was correlated to the severity of ARDS (P<0.0001). Correlation analysis showed that the levels of plasma galectin-3 were significantly correlated with APACHEⅡ score and PaO2/FiO2 ratio (Spearman’s rho = 0.44 and -0.616, respectively, P<0.0001). At an optimal cutoff of 10.58ng/mL, the sensitivity and specificity of galectin-3 for ICU 28-day mortality prediction were 81.48% (95% CI 61.9%, 93.6%) and 55.56% (95% CI 38.1%, 72.1%), respectively.