SESSION TITLE: Critical Care: ARDS/ALI
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: p38MAPK, a mitogen-activated protein kinase, plays a negative regulating role in the pathogenesis of acute respiratory distress syndrome (ARDS) induced by lipopolysaccharide (LPS). A p38MAPK inhibitor has previously been shown to alleviate inflammatory reaction. We recently proposed that the balance of T helper17 (Th17) and Treg cells regulated in this inflammatory conditions. In the present study, we investigated in vivo the effect of Th17/Treg balance on p38MAPK inhibitor relieved mild ARDS induced by LPS.