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Critical Care: Critical Care: ARDS/ALI |

p38MAPK Inhibitor Ameliorates Lipopolysaccharide-Induced Mild Acute Respiratory Distress Syndrome Through Regulating the Balance of Treg Cells and Th17 Cells

Jingjing Feng; Jindong Shi; Shanqun Li; Zhijun Jie, PhD
Author and Funding Information

The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A158. doi:10.1016/j.chest.2016.02.164
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SESSION TITLE: Critical Care: ARDS/ALI

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: p38MAPK, a mitogen-activated protein kinase, plays a negative regulating role in the pathogenesis of acute respiratory distress syndrome (ARDS) induced by lipopolysaccharide (LPS). A p38MAPK inhibitor has previously been shown to alleviate inflammatory reaction. We recently proposed that the balance of T helper17 (Th17) and Treg cells regulated in this inflammatory conditions. In the present study, we investigated in vivo the effect of Th17/Treg balance on p38MAPK inhibitor relieved mild ARDS induced by LPS.

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