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Critical Care: Critical Care: ARDS/ALI |

Losartan, a Selective Antagonist of AT1 Receptor, Attenuates Acute Lung Injury Induced by Seawater Inhalation in Rats

Faguang Jin, PhD
Author and Funding Information

Tangdu Hospital, Fourth Military Medical University, Xi'an, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A155. doi:10.1016/j.chest.2016.02.161
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SESSION TITLE: Critical Care: ARDS/ALI

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Losartan is a selective antagonist of Ang I type (AT1) receptor of Angiotensin II (Ang II), which is widely used as a clinical medicine for the hypertension. Furthermore losartan was shown to protect from acute lung injury (ALI) induced by lipopolysaccharides, acid aspiration, sepsis and ventilation. The aim of this research was to clarify whether Ang II participated in the inflammatory response of ALI induced by seawater inhalation, and whether losartan had the protective effects on ALI by blocking the combination of Ang II and AT1 receptor.

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