SESSION TITLE: Critical Care: ARDS/ALI
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Losartan is a selective antagonist of Ang I type (AT1) receptor of Angiotensin II (Ang II), which is widely used as a clinical medicine for the hypertension. Furthermore losartan was shown to protect from acute lung injury (ALI) induced by lipopolysaccharides, acid aspiration, sepsis and ventilation. The aim of this research was to clarify whether Ang II participated in the inflammatory response of ALI induced by seawater inhalation, and whether losartan had the protective effects on ALI by blocking the combination of Ang II and AT1 receptor.