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Critical Care: Critical Care: ARDS/ALI |

Dipeptidyl Peptidase IV Inhibition Ameliorates Pulmonary Fibrosis in Lipopolysaccharide-Induced Lung Injury by Inhibiting Endothelial-to-Mesenchymal Transition

Toshio Suzuki, MD; James West; Rintaro Nishimura, PhD; Takeshi Kawasaki, PhD; Ayumi Sekine, PhD; Takashi Urushibara, PhD; Yuji Tada, PhD; Koichiro Tatsumi, PhD
Author and Funding Information

Chiba University, Chiba, Japan


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A153. doi:10.1016/j.chest.2016.02.159
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SESSION TITLE: Critical Care: ARDS/ALI

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Pulmonary fibrosis is the final pathway of acute respiratory distress syndrome (ARDS). Recently, endothelial-to-mesenchymal transition (EndMT) had been shown to play an important role in pulmonary fibrosis. On the other hand, dipeptidyl peptidase (DPP)-4 was reported to play roles in EndMT in kidney. However its effects on EndMT and fibrosis initiation during lipopolysaccharide (LPS)-induced lung injury remain unknown. The aim of this study was to investigate the anti-EndMT effects of the DPP-4 inhibitor, vildagliptin in septic lung injury.

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