SESSION TITLE: Critical Care: ARDS/ALI
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Pulmonary fibrosis is the final pathway of acute respiratory distress syndrome (ARDS). Recently, endothelial-to-mesenchymal transition (EndMT) had been shown to play an important role in pulmonary fibrosis. On the other hand, dipeptidyl peptidase (DPP)-4 was reported to play roles in EndMT in kidney. However its effects on EndMT and fibrosis initiation during lipopolysaccharide (LPS)-induced lung injury remain unknown. The aim of this study was to investigate the anti-EndMT effects of the DPP-4 inhibitor, vildagliptin in septic lung injury.