CASE PRESENTATION: Original case 1 Male, 71 years old, with diabetes for 14 years, didn’t receive hypoglycemic agents, but only underwent diet-control and exercising; diagnosed “coronary heart disease” for 1 year. He was treated with biapenem 0.3g and linezolid 0.6g every 12 hours intravenous, On the 3rd day of his admission, the patient appeared diaphoresis, tremulousness and palpitation, these symptoms reliefed after taking food. On day 7, the patient got nosocomial infection and linezolid was reused. From day 8 to day 11, the hypoglycemia symptoms returned, the minimum value of blood glucose was 50.4 mg/dL, leading to a dextrose infusion. Original case 2 Male, 82 years old, denying diabetes history, treatment for him are as followed: biapenem 0.3g and linezolid 0.6g every 12 hours intravenous, On day 2, the patient appeared diaphoresis and palpitation with a minimum value of glucose reading 46.8 mg/dL. The symptoms disappeared after linezolid was stopped on the 4th day. Original case 3 Male, 84 years old, denying diabetes history, On day 8 he suffered hospital-associated infection, treated by cefoperazone-sulbactam 2.0g and linezolid 0.6g every 12 hours intravenous, 6 days after linezolid was prescribed, the patient appeared profuse sweating, glucose reading was 1.9mmol/L.