0
Chest Infections: Infections: Fungal |

Pharyngeal Infection of Penicilliosis marneffei in Acquired Immunodeficiency Syndrome Patients FREE TO VIEW

Jianquan Zhang, PhD
Author and Funding Information

The First Affiliated Hospital of Guangxi Medical University, Nanning, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A131. doi:10.1016/j.chest.2016.02.136
Text Size: A A A
Published online

SESSION TITLE: Infections: Fungal

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To describe the clinical and laryngoscopic features of pharyngeal infection with Penicilliosis marneffei in acquired immunodeficiency syndrome patients.

METHODS: A retrospective study was conducted between January 1, 2002 and April 1, 2015 at the First Affiliated Hospital of Guangxi Medical University. Patients who presented with culture and/or histopathological evidence of pharyngeal tissue infection with Penicilliosis marneffei were included.

RESULTS: The most common nonspecific symptoms were fever, malaise, weight loss and anemia. The most common specific symptoms were sore throat, pharyngeal and laryngeal lump, hoarseness, mucosal ulceration and multiple cervical and armpit lymphadenopathies. CD4 and CD8 lymphocyte counts, and the ratio of CD4/CD8 were decreased in all patients. Electronic laryngoscopy indicated pharyngeal ulcers and/or lumps. Penicillium marneffei was isolated from blood samples (2/2) and pharyngeal lesion tissue (6/6). All patients in our retrospective analysis were positive for Penicilliosis marneffei infection by histopathology of pharyngeal tissue samples.

CONCLUSIONS: Pharyngeal infection with Penicilliosis marneffei the specific symptoms detected by electronic laryngoscopy, namely pharyngeal ulcers and/or lumps, were difficult to differentiate from the symptoms of tuberculosis, lymphoma, pharyngeal cancer and Kaposi’s sarcoma. Histopathology and fungal culture of pharyngeal secretions and tissue are therefore important methods to obtain an accurate diagnosis of pharyngeal infection with Penicilliosis marneffei, ensuring timely and appropriate treatment for patients and ultimately a reduction in the mortality rate associated with this pathogen.

CLINICAL IMPLICATIONS: The specific symptoms detected by electronic laryngoscopy, namely pharyngeal ulcers and/or lumps, were difficult to differentiate from the symptoms of tuberculosis, lymphoma, pharyngeal cancer and Kaposi’s sarcoma. Histopathology and fungal culture of pharyngeal secretions and tissue are therefore important methods to obtain an accurate diagnosis of pharyngeal infection with Penicilliosis marneffei, ensuring timely and appropriate treatment for patients and ultimately a reduction in the mortality rate associated with this pathogen.

DISCLOSURE: The following authors have nothing to disclose: Jianquan Zhang

No Product/Research Disclosure Information


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543