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Chest Infections: Infections: Fungal |

Clinical Analysis of 78 Cases of Invasive Fungal Diseases FREE TO VIEW

Zaiyi Wang
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First Teaching Hospital of Xinjiang Medical University China, Urumqi, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A130. doi:10.1016/j.chest.2016.02.135
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SESSION TITLE: Infections: Fungal

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Objective Clinical analysis was conducted on 78 confirmed cases of invasive fungal infections to explore the clinical features.

METHODS: 78 cases of fungal infection confirmed by the First Teaching Hospital of Xinjiang Medical University by means of pathology and sterile fluid culture positive from August 1 2008 to August 1 2013 were enrolled. The diagnostic criteria referred to research group and consensus group of European Organization for Research and Treatment of Cancer (EORIC/MSG) /Cooperative group of invasive fungal infections and fungal disease group of National Allergic Reaction and Infectious Disease Research Institute (USA).

RESULTS: 78 cases were enrolled in total in the study, among which there were 40 cases of candida, 25 cases of aspergillus, 8 cases of Cryptococcus, 1 case of mucor and 4 cases of unclassified ones. There were 33 cases of pulmonary fungal infection. Underlying diseases combined with fungal infection were as follows successively: 35 cases of cardia-cerebrovascular diseases, 20 cases of endocrine system disease, 16 cases of respiratory diseases and 13 tumors. Most candida invasive infections take the form of candidemia (77.5%). Death rate of 40 cases of invasive candidal infections was 50%. There were 25 cases of pulmonary aspergillus infection, the clinical manifestation of which were mainly hemoptysis, cough, fever accompanied with symptoms of dyspnea and expectoration.

CONCLUSIONS: 1. Systemic invasive fungal infections were mainly cadidiasis and among candida, candida albicans were still the main strain. However, pulmonary fungal infections were mainly aspergilllus infection. 2. Pulmonary aspergillus infections were usually observed in patients with structural change and necrosis of pulmonary tissue and in population without significant risk factors. 3. Use of indwelling catheters and long-term antibiotics was more likely to cause secondary infection of candida. 4. Onset of Cryptococcus may occur among population with normal immune function and the overall prognosis was fairly good in case of early discovery.

CLINICAL IMPLICATIONS: The paper is to make retrospective analysis on fungal infection diseases confirmed by pathology and sterile body fluid culture in recent 5 years in the First Teaching Hospital of Xinjiang Medical University and summarizes the principle to guide clinic.

DISCLOSURE: Zaiyi Wang: Other: no

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