Chest Infections: Infections: Fungal |

Clinical Analysis of 41 Immunocompetent Patients With Pulmonary Nocardiosis in Mainland China FREE TO VIEW

Penny Tseng, MS; Feng Ye, MD
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The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A123. doi:10.1016/j.chest.2016.02.128
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SESSION TITLE: Infections: Fungal

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: This article aim to make further understanding of the clinical features, images and etiology of the pulmonary Nocardiosis in immunocompetent host.

METHODS: Data are collected from 9 cases immunocompetent hosts with pulmonary nocardiosis hospitalized in Guangzhou Medical University first affiliated hospital and 32 cases reported in cnki, cqvip, CBM from January 2012 to May 2015. we analysed the clinical features, imaging and etiology of these patients.

RESULTS: There were 25 male patients (60.98%) and 16 female patients (39.02%). Median age of the patients was 55.23±18.22 (range, 3.5 to 82 y). 17 of 41 immunocompetent hosts with pulmonary Nocardiosis suffering from structural lung disease (41.46%) including bronchiectasis, Chronic obstructive pulmonary disease (COPD) and Lung cysts. In this review, the common manifestations of immunocompetent hosts with pulmonary Nocardiosis included fever, cough, expectoration, dyspnea, hemoptysis, chest pain and weight loss. 10 cases accompanied pleural effusion, 7 cases with lung abscess. Dissemination occurred in 10 cases, dissemination parts included the brain, skin, abdominal wall. Common chest image were nodules (16 cases), consolidation (12cases), cavity, mass (12 cases) and patchy (9 cases). Nocardia asteroids predominant in 23 identified Nocardia. Most of Nocardia are susceptible to Sulfonamides in drug sensitivity test. Major patients had good prognosis.

CONCLUSIONS: Structural lung disease maybe is risk factors for the immunocompetent hosts with pulmonary Nocardiosis.

CLINICAL IMPLICATIONS: The common manifestations of pulmonary nocardiosis were cough (92.68 %), expectoration (90.24 %), fever (82.93 %), dyspnea (46.34%). 10 patients accompanied with peural effusion (24.39%) and 7 with lung abscess (17.07%). Dissemination also occurred in immunocompetent hosts. Dissemination part including the brain, skin and abdominal wall.

DISCLOSURE: The following authors have nothing to disclose: Penny Tseng, Feng Ye

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