CASE PRESENTATION: A 62-year-old with IgG Lambda Myeloma s/p autologous bone marrow transplant at day 147 was admitted with diarrhea, rash, fatigue, and right arm pain. On exam, her blood pressure was 108/67 mmHg, heart rate was 94 beats/minute and she was afebrile. She had edema in her right leg and arm and a rash on her chest. She was pancytopenic and chest radiograph (CXR) showed a right lower lobe infiltrate and a pathologic arm fracture. She was admitted for fracture repair and antibiotics. On hospital day 12, she developed acute respiratory failure. CXR showed bilateral pulmonary infiltrates. Cultures were positive for stenotrophomonas. On hospital day 19, she developed worsening oxygenation and shock. Antibiotics were broadened to included Bactrim as a CXR revealed a new right upper lobe lung mass confirmed on chest computed tomography as a lobulated 5 x 5.1 cm mass. On hospital day 22, blood cultures grew Norcardia, but despite aggressive treatment and several days on bactrim, she developed worsening hemodynamic instability with organ failure. The family requested withdrawal of life sustaining therapy. An autopsy was performed. Systemic amyloidosis was present involving the heart, lungs, and multiple additional tissues. Widespread angioinvasive zygomycosis was found involving the heart, mediastinum and the hemorrhagic lung lesion.