Chest Infections: Chest Infections: Bacterial |

A Controversial Research Approach: How a Polymer Coated Nanoceria-Based System Can Have Antibacterial Behavior FREE TO VIEW

Narcisa Vrinceanu, PhD; Paraschiva Postolache, MD; Cristina Mihaela Rimbu, PhD
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Lucian Blaga University of Sibiu and “Al. I. Cuza” University of Iasi, Iasi, Romania

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A99. doi:10.1016/j.chest.2016.02.104
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SESSION TITLE: Chest Infections: Bacterial

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Our research is focused onto a biocompatible system based on polymer-coated cerium oxide nanoparticles (nanoceria). The starting point envisages the nanoceria ability to transition from Ce+3 to Ce+4, conducting to a barrier behaviour for living systems against oxidative stress. Despite the fact that numerous reports highlight nanoceria’s role as potential antioxidant towards intracellular reactive oxygen species, due to scavenging the free radicals, according to our knowledge, their antibacterial response has been barely touched upon scientific works. More over our study centers on the essence that the nanoceria’s architecture attributes can be tailored in a predictable manner to fulfil the requirements of antibacterial performance against both the Gram positive and Gram negative bacterial strains.

METHODS: The nanoceria with different surface architectures were synthesized. The synthesis relies on an alkaline-based precipitation of cerium oxide (Ce2O3:CeO2) from a solution containing a cerium salt and poly-lactic acid (PLA). The co-assisted characterization system of PLA-coated nanoceria: Scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis and X-ray photoelectron spectroscopy (XPS) of PLA-coated nanoceria reveals their profile.

RESULTS: The morphology of nanocrystals with an average size of 5-6 nm; a face-centred-regular core with lattice planes; occurrence of a mixed valence state in PLA-coated nanoceria, giving the corresponding binding energy peaks for Ce+3 and Ce+4, thus assuming that the PLA coating does not affect its mixed valence state. This new bioavailable platform showed stability in PBS (phosphatebuffered saline) and water durability, without any aggregation or sedimentation, meaning that the chosen water based synthesis method proves a positive key point over the organic solvent based synthetic methodologies.

CONCLUSIONS: The study stresses the antibacterial role of PLA-coated nanoceria against gram-negative bacteria and gram-positive bacteria in terms of synthesis conditions, and architecture features, like: dimensions, surface condition, charge, structural arrangement and morphology.

CLINICAL IMPLICATIONS: The originality relies on the fact that, contrary to the assumption with scientific fundamentals that nanoceria can induce severe pulmonary diseases, when coated with a polymer, they can modify their corresponding toxicity with respect to bacteria, like: Klebsiella pneumoniae, E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, etc involved in bacterial pneumonia.

DISCLOSURE: The following authors have nothing to disclose: Narcisa Vrinceanu, Paraschiva Postolache, Cristina Mihaela Rimbu

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