RESULTS: Out of the 1,0128 cases, 1522 (15%) pathogens were isolated. Gram-negative bacteria is the major isolates, accounting for 90% of all positive specimens, followed by Gram-positive bacteria, accounting for 9.7% of the positive specimens. The top five common Gram-negative bacteria identified were Pseudomonas aeruginosa (29.43%), Klebsiella pneumoniae (28.06%), Escherichia coli (5.91%), Bauman Acinetobacter (4.73%), Enterobacter cloacae (4.73%). The top five common Gram-positive bacteria identified were Streptococcus pneumoniae (4.99%), Staphylococcus aureus (2.89%), Streptococcus viridans (0.59%), Enterococcus faecalis (0.26%) and coagulase negative staphylococcus (0.26%). The susceptive rate for Klebsiella pneumoniae (including ESBL+) of meropenem was 100%, and antimicrobial resistant rate of ESBLs-producing K. pneumoniae isolates of all drugs in antimicrobial susceptibility test showed declining trend year by year. The susceptive rate for Escherichia coli (including ESBL+) of imipenem was 100%, and the antimicrobial resistant rate for it of meropenem was decreased. The antimicrobial resistant rate for Acinetobacter baumannii of piperacillin / tazobactam, imipenem, meropenem, amikacin showed downward trend. The susceptive rate for Staphylococcus aureus of linezolid and teicoplanin was 100%, while resistant rate for it of penicillin was 97%.