Chest Infections: Chest Infections: Bacterial |

Analysis of Pathogens and Antimicrobial Resistance in Lower Respiratory Tract Bacterial Infection FREE TO VIEW

Ying Liu; Haibo Yuan; Jing Jie; Shaomin Wang; Liping Peng
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The First Hospital of Jilin University, Changchun, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A91. doi:10.1016/j.chest.2016.02.096
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SESSION TITLE: Chest Infections: Bacterial

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The distribution and antimicrobial resistance of lower respiratory tract infection pathogens in Jilin province.

METHODS: A total of 1,0128 sputum samples from inpatients in Department of respiratory of the first hospital of Jilin University and group hospitals between 2012 and 2014 were collected and cultured, and antibiotic susceptibility of bacteria were tested.

RESULTS: Out of the 1,0128 cases, 1522 (15%) pathogens were isolated. Gram-negative bacteria is the major isolates, accounting for 90% of all positive specimens, followed by Gram-positive bacteria, accounting for 9.7% of the positive specimens. The top five common Gram-negative bacteria identified were Pseudomonas aeruginosa (29.43%), Klebsiella pneumoniae (28.06%), Escherichia coli (5.91%), Bauman Acinetobacter (4.73%), Enterobacter cloacae (4.73%). The top five common Gram-positive bacteria identified were Streptococcus pneumoniae (4.99%), Staphylococcus aureus (2.89%), Streptococcus viridans (0.59%), Enterococcus faecalis (0.26%) and coagulase negative staphylococcus (0.26%). The susceptive rate for Klebsiella pneumoniae (including ESBL+) of meropenem was 100%, and antimicrobial resistant rate of ESBLs-producing K. pneumoniae isolates of all drugs in antimicrobial susceptibility test showed declining trend year by year. The susceptive rate for Escherichia coli (including ESBL+) of imipenem was 100%, and the antimicrobial resistant rate for it of meropenem was decreased. The antimicrobial resistant rate for Acinetobacter baumannii of piperacillin / tazobactam, imipenem, meropenem, amikacin showed downward trend. The susceptive rate for Staphylococcus aureus of linezolid and teicoplanin was 100%, while resistant rate for it of penicillin was 97%.

CONCLUSIONS: Gram-negative bacteria is most common pathogens in the lower respiratory tract infection, the antimicrobial resistance rates of some pathogens were significantly decreased. Meropenem was the first choice for antibiotic treatment of Klebsiella pneumoniae (including ESBL+). Imipenem was the first choice for Escherichia coli (ESBL+) infections. Staphylococcus aureus infections preferred linezolid and teicoplanin.

CLINICAL IMPLICATIONS: Provide theoretical basis for clinical empirical application of antimicrobial agents, Encourage rational use of antibiotics, reduce resistance strains.

DISCLOSURE: The following authors have nothing to disclose: Ying Liu, Haibo Yuan, Jing Jie, Shaomin Wang, Liping Peng

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