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Chest Infections: Chest Infections |

The Clinical Characteristics of Rhinoviruses Infections in Adult Community-Acquired Pneumonia FREE TO VIEW

Keqiang Wang, MD
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Peking University People's Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A87. doi:10.1016/j.chest.2016.02.092
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SESSION TITLE: Chest Infections

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 02:15 PM - 03:45 PM

PURPOSE: Rhinovirus is the mostly common etiology of upper respiratory tract infections. However, its role in lower respiratory tract infections is still uncertain. Our study was aimed to understand the role of rhinoviruses in lower respiratory tract infections in adults.

METHODS: The patients who were admitted to hospitals with pneumonia in January 2013 to December 2014 were enrolled in multiple centers in mainland China. The clinical data and respiratory tract samples (bronchoalveolar lavage fluid) were collected. Multiple reverse-transcription polymerase chain reaction for virus nucleic acid were implemented in all the specimens. The clinical traits for lower respiratory tract infections patients whose sample was rhinoviruses-positive were analyzed.

RESULTS: Of 383 patients with pneumonia in 2-year period, 20 patients were rhinovirus-positive. 12 cases were diagnosed severe pneumonia. While 15 of them were males, 7 of the patients were in the group >= 65 years old. The most common symptoms included cough (19), fever (17) and expectoration (15). 11 cases showed leukocytosis (median 11.2*109/L, ranged from 2.66*109/L to 20.3*109/L), with a high percentage of neutrophils (median 84.6%, from 40.7% to 97.2%). 12 cases had bilateral involvement in radiologic findings, in 5 cases pleural effusion was found. 12 patients showed respiratory failure (PaO2/FiO2<300). The outcomes turned to draw more attention, while 5 (25%) patients died.

CONCLUSIONS: Rhinovirus most likely played a more important role than we thought in lower respiratory tract in adults, especially in severe pneumonia. Further investigation are warranted.

CLINICAL IMPLICATIONS: Rhinovirus most likely played a more important role than we thought in community acquired pneumonia in adults, especially in severe pneumonia. The HRV pneumonia couldn’t be distinguished by symptoms, physical examinations, laboratory test even radiography from other pneumonia.

DISCLOSURE: The following authors have nothing to disclose: Keqiang Wang

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