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Chest Infections: Chest Infections |

Pharmacologic Ascorbate Treatment of Influenza A In Vitro and In Vivo in Mice

Linling Cheng, MD
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Guangzhou Institute of Respiratory Disease, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A83. doi:10.1016/j.chest.2016.02.088
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SESSION TITLE: Chest Infections

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The possibility exists for an influenza pandemic, and new treatments are needed. We postulated that hydrogen peroxide generated by pharmacologic vitamin C had antiviral properties.

METHODS: Ascorbate was analyzed with HPLC and H2O2 was measured by Clark electrode. NHBE cells infected with virus were treated with ascorbic acid, then harvested to determine virus titer. BALB/c mice infected intranasally with influenza virus were treatments with ascorbic acid, and lung were havested for viral titration and histopathologic evaluation

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