DISCUSSION: The incidence of aspergillus pleural empyema thoracis is often correlated with the host impaired denfense, pyopneumothorax or chronic lung lesions as bronchiectatic cavities or tuberculosis sequelae. This current patient history of lobecomy for a bleb and cyst infection and, didn’t have a satisfied response of broad spectrum antibiotic therapy but later the etiology confirmed. Prompt rigid medical thoracoscopy to clean the necrotic material in pleural cavity plays a vital role for successful treatment of aspergillus thoracis. Secondly systemically or locally used of anti-fungal as voriconazole, a potentially safe, effective first-line drugs with minimum probability of resistance to aspergillus fumigatus, is another important factor. Thirdly drainage and wash pleural cavity every day is also very important.