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Cardiothoracic Surgery: Cardiothoracic |

Comparison of Blood Flow Dynamics in Post-Operation CoA Patients With Different Levels of Restenosis on MRIs FREE TO VIEW

Qiong Yao, PhD; Xi-hong Hu, PhD; Quan-li Shen, PhD; Zhong-wei Qiao, PhD
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Children's Hospital of Fudan University, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A63. doi:10.1016/j.chest.2016.02.066
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SESSION TITLE: Cardiothoracic

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Coarctation of the aorta (CoA) is associated with post-operation restenosis despite treatment. Abnormal hemodynamics is implicated and will provide understanding for the pathogenesis of aortic disease. We present the quantification of restenosis-induced hemodynamics alterations and the comparison in four patients with different levels of restenosis based on MR images.

METHODS: Four patients with different restenosis were included in the research: slight (<20%), medium (20∼50%), severe (>50%) and one slight stenosis with distortion. MR images were DICOM format and phase contrast sequence provided the inlet velocity-time curve. Three-dimensional model for simulation was obtained by Mimics 17.0 and Fluent 15.0 was applied to simulate the blood flow within the thoracic aorta. The relevant hemodynamic parameters included velocity map, pressure map and time-averaged wall shear stress (WSS).

RESULTS: The hemodynamic parameters of thoracic aorta at different time during a cardiac cycle were calculated. The proximal region before stenosis had higher pressure and WSS, but reduced in the distal region after stenosis. Patients with less stenosis had less vortex and turbulence, the impinging velocity jet could be less severe as well. For patient with distortion, the vortex and turbulence could be more severe and extended to the distal region of the descending aorta.

CONCLUSIONS: The blood flow in aortic stenosis during the cardiac cycle is complex, which shows large changes in vortex, turbulence, pressure and wall stress according to the shape of the vessels. The distortion could also cause obvious hemodynamic abnormalities.

CLINICAL IMPLICATIONS: The post-operation CoA patients need long-term follow-up and focusiong on the aorta disorders with severe hemodynamic alteration.

DISCLOSURE: The following authors have nothing to disclose: Qiong Yao, Xi-hong Hu, Quan-li Shen, Zhong-wei Qiao

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