RESULTS: miMRST was performed for 33 aging, cardiopulmonary dysfunction patients, including 11 wedge resection: 5 harmartoma, 2 inflammatory pseudotumor, 2 tuberculoma, 1 minimally invasive adenocarcinoma (MIA) and 2 adenocarcinoma; 3 lobectomy: 1 hemangioma, 1 pulmonary sclerosing hemangioma and 1 inflammatory pseudotumor; and 18 lobectomy plus mediastinal lymph node dissection: 5 adenocarcinoma in situ (AIS) and 13 adenocarcinoma. VATS was performed for 10 patients, including 5 video-assisted minithoracotomy (VAMT) cases: 3 wedge resection for 2 adenocarcinoma and 1 hemangioma, 2 lobectomy plus mediastinal lymph node dissection for adenocarcinoma; 2 complete VATS: 1 lobectomy for pulmonary sclerosing hemangioma, 1 lobectomy plus mediastinal lymph node dissection for adenocarcinoma; 3 uniportal VATS: wedge resection for 1 MIA, 1 metastasis tumor and 1 inflammatory myofibroblastic tumor. SPLT was performed for 52 adenocarcinoma patients, including 2 wedge resection and 50 lobectomy plus mediastinal lymph node dissection. The average incision length is about 11cm in miMRST, 8cm in VATS and 35cm in SPLT (P<0.001). When compared with SPLT, patients showed less pains from miMRST and VATS, operative-side upper limb recovered freedom of movement quickly and better; walking earlier; chest tube drainaged less and was pulled out earlier; almost no complication happened; could be discharged earlier (P<0.05).