Cardiothoracic Surgery: Cardiothoracic |

Combination US-Guided Cutting-Needle Biopsy and Standard Pleural Biopsy for Diagnosis of Unilateral Pleural Effusions: A Novel Approach FREE TO VIEW

Jinlin Wang, MD; Xiaohong Xie, MD; Yunxiang Zeng, MD; Shiyue Li, MD
Author and Funding Information

The State Key Laboratory of Respiratory Disease, China Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A59. doi:10.1016/j.chest.2016.02.062
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SESSION TITLE: Cardiothoracic

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The search for the most efficient approach for diagnosis of unilateral pleural effusions (UPE) is still active. The major aim of this study was to determine sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy of US-guided cutting-needle biopsy (CNB) or standard pleural biopsy (SPB) and their combination in diagnosis of UPE.

METHODS: Pleural effusions were collected to analysis for biochemical and microbiological in all subjects, then US-guided CNB were performed in one side and SPB were performed in another side to acquire material for histological analysis.

RESULTS: A total of 86 patients (53 males and 33 females; average age, 52.4±4.8 years) with UPE were enrolled. 90.7% and 94.2% procedures of CNB and SPB provided adequate material for histological analysis. The sensitivity, specificity, PPV, NPV and diagnostic accuracy of US-guided CNB were 70.7%, 100%, 100%, 75.5%, 84.6%, respectively; the corresponding values for SPB were 68.3%, 100%, 100%, 75.5%, 84.0%, respectively; while the values for combination of CNB and SPB were 92.7%, 100%, 100%, 93.6% and 96.5%, respectively. Combination of CNB and SPB significantly improves sensitivity, specificity and diagnostic accuracy when compared to each individual technique (P < 0.001). An asymptomatic pneumothorax was present in one patient with no chest tube placement required.

CONCLUSIONS: Combination of US-guided CNB and SPB in diagnosis of UPE increases sensitivity, specificity and diagnostic accuracy of each technique. It is a safe and novel approach for diagnosis of UPE.

CLINICAL IMPLICATIONS: Combination of US-guided CNB and SPB can be as a novel approach to diagnose of UPE.

DISCLOSURE: The following authors have nothing to disclose: Jinlin Wang, Xiaohong Xie, Yunxiang Zeng, Shiyue Li

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