DISCUSSION: PCL is defined as a Non-Hodgkin’s Lymphoma, most commonly DLBCL, which originates in the lymphatics around the heart and pericardium, and does not involve any other organ.2 It represents only 0.5% of all forms of extranodal lymphoma.1 Although extremely rare in immunocompetent patients, reports of PCL in patients with HIV and solid organ transplantation is on the rise. The mean age of presentation is 63 and there is a male:female predominance of 1.94. Most patients present with signs of arrhythmias, heart failure, tamponade, or syncope due to a myxoma effect.2 Over 90% originate in the right chambers, 41% involve the atrial septa, and 80% present with pericardial disease. PCL is extremely sensitive to chemotherapy, but unfortunately the treatment may cause sudden-death if there is rapid necrosis of the tumor leading to cardiac wall rupture. Our patient was very fortunate in regards to being diagnosed early, with only echocardiographic tamponade, and underwent chemotherapy without complications.