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Allergy and Airway: Asthma IV |

Human β-defensin-2 and -3 Induce IL-8 Release Through CCR6 in Human Airway Smooth Muscle Cells

Wei-Jia Wang; Xiao-Yan Qu; Xiao-Min Dang; Dong Shang; Dan Xu; Yong-Ping Shao; Wu-Yuan Lu; Ying Chang, PhD
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Center for Translational Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi'an, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A41. doi:10.1016/j.chest.2016.02.043
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SESSION TITLE: Asthma IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Human airway smooth muscle cells (HASMCs) play an important role in the pathogenesis of airway remodeling in asthma. HASMCs are involved in the inflammatory response through the release of inflammatory mediators. Human β-defensin (HBD) is a sub-family of small antimicrobial peptides, characterized by six conserved cysteines which compose a largely b-sheet structure by three intramolecular disulfides. Increasing evidence indicates that HBDs are related to pathogenesis of asthma. In this study, we investigated the effect of HBD-1, 2 and 3 on the release of pro-inflammatory cytokine IL-8 by HASMCs and explored the involving receptors.

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