SESSION TITLE: Asthma IV
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Human airway smooth muscle cells (HASMCs) play an important role in the pathogenesis of airway remodeling in asthma. HASMCs are involved in the inflammatory response through the release of inflammatory mediators. Human β-defensin (HBD) is a sub-family of small antimicrobial peptides, characterized by six conserved cysteines which compose a largely b-sheet structure by three intramolecular disulfides. Increasing evidence indicates that HBDs are related to pathogenesis of asthma. In this study, we investigated the effect of HBD-1, 2 and 3 on the release of pro-inflammatory cytokine IL-8 by HASMCs and explored the involving receptors.